A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry
Identifieur interne : 001138 ( Main/Exploration ); précédent : 001137; suivant : 001139A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry
Auteurs : Mona K. Beyer [Norvège] ; Carmen C. Janvin [Norvège] ; Jan P. Larsen [Norvège] ; Dag Aarsland [Norvège]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2007-03.
English descriptors
- KwdEn :
- ANCOVA, analysis of covariance, ANOVA, analysis of variance, FWE, family-wise error, MCI, mild cognitive impairment, MMSE, Mini-Mental State Examination, MRI, magnetic resonance imaging, PDD, Parkinson’s disease with dementia, PDND, Parkinson’s disease without dementia, SPM, statistical parametric mapping, SVC, small volume correction, VBM, voxel-based morphometry.
Abstract
Background: Dementia is common in Parkinson’s disease, but the underlying brain pathology is not yet fully understood. Aim: To examine the changes in the brain of patients with Parkinson’s disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging. Methods: Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson’s disease and dementia (PDD; n = 16) and Parkinson’s disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used. Results: Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found. Conclusion: These findings show that dementia in Parkinson’s disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.
Url:
DOI: 10.1136/jnnp.2006.093849
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Larsen</name></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1136/jnnp.2006.093849</idno><idno type="url">https://api.istex.fr/document/1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001283</idno><idno type="wicri:Area/Main/Curation">001078</idno><idno type="wicri:Area/Main/Exploration">001138</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry</title><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K" last="Beyer">Mona K. Beyer</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Radiology, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Janvin, Carmen C" sort="Janvin, Carmen C" uniqKey="Janvin C" first="Carmen C" last="Janvin">Carmen C. Janvin</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P" last="Larsen">Jan P. Larsen</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Geriatric Psychiatry, Centre for Clinical Neuroscience Research, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2007-03">2007-03</date><biblScope unit="volume">78</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="254">254</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5</idno><idno type="DOI">10.1136/jnnp.2006.093849</idno><idno type="href">jnnp-78-254.pdf</idno><idno type="PMID">17028119</idno><idno type="local">0780254</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ANCOVA, analysis of covariance</term><term>ANOVA, analysis of variance</term><term>FWE, family-wise error</term><term>MCI, mild cognitive impairment</term><term>MMSE, Mini-Mental State Examination</term><term>MRI, magnetic resonance imaging</term><term>PDD, Parkinson’s disease with dementia</term><term>PDND, Parkinson’s disease without dementia</term><term>SPM, statistical parametric mapping</term><term>SVC, small volume correction</term><term>VBM, voxel-based morphometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Dementia is common in Parkinson’s disease, but the underlying brain pathology is not yet fully understood. Aim: To examine the changes in the brain of patients with Parkinson’s disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging. Methods: Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson’s disease and dementia (PDD; n = 16) and Parkinson’s disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used. Results: Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found. Conclusion: These findings show that dementia in Parkinson’s disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.</div></front></TEI><affiliations><list><country><li>Norvège</li></country></list><tree><country name="Norvège"><noRegion><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K" last="Beyer">Mona K. Beyer</name></noRegion><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><name sortKey="Janvin, Carmen C" sort="Janvin, Carmen C" uniqKey="Janvin C" first="Carmen C" last="Janvin">Carmen C. Janvin</name><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P" last="Larsen">Jan P. Larsen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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